Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis.

@article{Berge2001Prx1AP,
  title={Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis.},
  author={Derk ten Berge and Alex Brouwer and Jeroen Korving and Marlene J. Reijnen and E J van Raaij and Fons Verbeek and William Gaffield and Frits C. P. W. Meijlink},
  journal={Development},
  year={2001},
  volume={128 15},
  pages={2929-38}
}
The aristaless-related homeobox genes Prx1 and Prx2 are required for correct skeletogenesis in many structures. Mice that lack both Prx1 and Prx2 functions display reduction or absence of skeletal elements in the skull, face, limbs and vertebral column. A striking phenotype is found in the lower jaw, which shows loss of midline structures, and the presence of a single, medially located incisor. We investigated development of the mandibular arch of Prx1(-/-)Prx2(-/-) mutants to obtain insight… CONTINUE READING
26 Citations
35 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 35 references

Control of

  • R. J. Wechsler-Reya, M. P. Scott
  • NEURONAL
  • 1999

Similar Papers

Loading similar papers…