Pruritus in Chronic Hepatitis C (Association with High Serum Bile Acids, Advanced Pathology, and Bile Duct Abnormalities)

@article{Lebovics2004PruritusIC,
  title={Pruritus in Chronic Hepatitis C (Association with High Serum Bile Acids, Advanced Pathology, and Bile Duct Abnormalities)},
  author={Edward Lebovics and F. Seif and David Kim and Abdelmonem Elhosseiny and Brad M. Dworkin and Ana Casellas and Susanne Bennett Clark and William S. Rosenthal},
  journal={Digestive Diseases and Sciences},
  year={2004},
  volume={42},
  pages={1094-1099}
}
Pruritus is a common symptom of chroniccholestatic liver diseases but is considered rare inchronic hepatitis. We observed pruritus to be anunusually common complaint in patients with advancedchronic hepatitis C. We reviewed the records of 175chronic hepatitis C patients to identify patients withsevere, diffuse, unexplained pruritus; 12 consecutiveprospective patients undergoing liver biopsy for chronic hepatitis C served as controls.Assessment included laboratory biochemical tests andassessment… 
Pruritus in patients with chronic liver disease and serum autotaxin levels in patients with primary biliary cholangitis
TLDR
Serum autotaxin is useful for assessing liver fibrosis and severity of cholangitis; however, it is not a predictive marker for severe pruritus in patients with PBC.
The Role of Hepatitis C Virus Infection in Patients with Chronic Generalized Pruritus
TLDR
The incidence of HCV infection in patients with generalized pruritus was compared to that of the control group, which comprised 100 dermatology outpatients withoutPruritus, crossmatching for age and gender with the patient group as 2 controls for each patient.
Cholestatic Presentation of Chronic Hepatitis C: A Clinical and Histological Study with a Review of the Literature
TLDR
Evidence of bile duct injury was seen in all patients and tended to be more severe than in controls, and a subset of patients with chronic hepatitis C may present with prominent cholestatic features, which may be progressive.
Increased Levels of γGT Suggest the Presence of Bile Duct Lesions in Patients with Chronic Hepatitis C
Damage to bile ducts in chronic hepatitis C is a characteristic histological lesion. Moreover, the presence of abnormal levels of γGT in these patients is also a common finding. Assessing whether the
Study of pruritus in chronic hepatitis C patients.
TLDR
Patients with chronic hepatitis C experiencePruritus more than those without, and serum TARC levels do not correlate with pruritus severity, and no significant differences were observed between the IFN- treated and non-IFN-treated groups.
A Clinical–Morphological Study on Cholestatic Presentation of Nonalcoholic Fatty Liver Disease
TLDR
NAFLD patients with biochemical cholestasis have a histological picture of bile damage; they have more advanced histological impairment than patients matched for age, sex and body mass index.
Determination of hepatitis C virus genotypes in pruritus patients in saudi arabia.
TLDR
HCV genotype 4 is the most predominant genotype among thePruritus patients and warrants larger studies in different ethnicities to find the molecular association between HCV genetic variants and pruritus.
Effect of molecular adsorbent recirculating system in hepatitis C virus‐related intractable pruritus
  • C. Doria, L. Mandala', +7 authors V. Scott
  • Medicine
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2003
TLDR
Although it is observed that a decreased level of serum bile acids was observed in patients treated with MARS, one cannot conclude that this was the mechanism of action for the reduction in pruritus intensity in patients in this series.
Pruritus in chronic liver disease: Mechanisms and treatment
  • N. Bergasa
  • Medicine
    Current gastroenterology reports
  • 2004
TLDR
Therapeutic interventions have concentrated on the removal of presumed and unknown pruritogens from the circulation, hepatic enzyme induction, and, over the past decade, opiate antagonists, the first specific treatment for the pruritus of cholestasis, which are promising but must be tested in properly controlled behavioral trials.
Pruritus in chronic cholestatic liver disease.
Pruritus is a troublesome complication in patients with cholestatic liver disease. Several links to its pathogenesis have been proposed, including the role of bile acids, endogenous opioid and
...
1
2
3
4
...

References

SHOWING 1-10 OF 21 REFERENCES
Itch in Liver Disease: Facts and Speculations
TLDR
Additional data concerning the relationship of pruritus to bile acid retention are presented and it is suggested that the type of cholestatic disorder, and not simply the magnitude of the cholESTasis, as estimated by the elevation of serum bile acids, is important.
Hepatitis C: A Multifaceted Disease: Review of Extrahepatic Manifestations
TLDR
The high prevalence of coexisting essential mixed cryoglobulinemia and hepatocellular abnormalities, it was postulated that hepatotrophic viruses may be involved in the pathogenesis of this disease.
Assessment of Hepatitis C Viremia Using Molecular Amplification Technologies: Correlations and Clinical Implications
TLDR
The level of HCV viremia correlates with the clinical stage of disease; patients with advanced stages of liver disease such as severe chronic active hepatitis, cirrhosis, and endstage liver disease had higher serum levels ofHCV RNA than patients with mild HCV infections.
Pathological diagnosis of chronic hepatitis C: a multicenter comparative study with chronic hepatitis B. The Hepatitis Interventional Therapy Group.
TLDR
These four histological lesions are useful pathological parameters in the diagnosis of liver disease caused by HCV and are likely to be seen in HCV than in HBV infection.
Hepatitic bile duct injuries in chronic hepatitis C: histopathologic and immunohistochemical studies.
  • K. Kaji, Y. Nakanuma, +6 authors M. Gershwin
  • Medicine
    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
  • 1994
TLDR
Analysis of needle biopsies from patients with chronic hepatitis C revealed that advancement of chronic hepatitis and the degree of necroinflammatory processes of the liver, particularly in the portal tracts, were positively correlated with the occurrence of hepatitic bile duct injuries.
Chronic hepatitis C and skin diseases: a review.
TLDR
Two case reports are presented to outline the pertinent findings in hepatitis C-related cryoglobulinemia, leukocytoclastic vasculitis, and lichen planus and discuss the main disorders associated with chronic HCV infection.
Measurements of iron status in patients with chronic hepatitis.
TLDR
In patients with chronic hepatitis in whom hereditary hemochromatosis is suspected, a liver biopsy should be performed with quantitation of hepatic iron and calculation of the hepaticIron index to confirm the diagnosis.
Pruritus as a symptom of hepatitis C.
TLDR
The symptom of pruritus should be added to a growing list of cutaneous manifestations of this newly recognized inflammatory viral hepatitis.
The nomenclature of chronic active hepatitis: an obituary.
Use of the terms chronic active hepatitis, chronic persistent hepatitis, and chronic lobular hepatitis should be discontinued in favor of an etiologic terminology. Inflammatory activity and necrosis
Effects of Naloxone Infusions in Patients with the Pruritus of Cholestasis: A Double-Blind, Randomized, Controlled Trial
TLDR
In eight pruritic patients with primary biliary cirrhosis, scratching activity was 29% to 96% less during naloxone infusions than during infusions of a placebo solution, and this result required confirmation by a double-blind, controlled study.
...
1
2
3
...