• Corpus ID: 35589965

Pruritus: a review.

  title={Pruritus: a review.},
  author={Elke Weisshaar and Michael J Kucenic and Alan B. Fleischer},
  journal={Acta dermato-venereologica. Supplementum},
The history, neurophysiology, clinical aspects and treatment of pruritus are reviewed in this article. The different forms of pruritus in dermatological and systemic diseases are described, and the various aetiologies and pathophysiology of pruritus in systemic diseases are discussed. Lack of understanding of the neurophysiology and pathophysiology of pruritus has hampered the development of adequate therapies. Nevertheless, the discovery of primary afferent neurons and, presumably, second… 

A review of itch: causes, neurophysiology, interpretation, and treatment options

A body of research has emerged that has shed light on many of the mechanisms governing itch, and numerous topical, systemic, and light-based options for therapy, many of which may provide well-tolerated and efficacious long-term treatment for this common complaint.

General Principles and Guidelines

Topical and systemic antipruritic therapies have to be worked out individually in recognition of age, preexisting diseases, medications, allergies, severity of pruritus, and impact on quality of life.

Pruritus in selected dermatoses.

Mechanisms responsible for pruritus and the most important dermatoses in which this symptom is found are presented and treatment of pruritic dermatoses is presented.

Current concepts of pathophysiology, epidemiology and classification of pruritus.

  • M. Jovanovic
  • Medicine, Biology
    Srpski arhiv za celokupno lekarstvo
  • 2014
Discovery of pruritus-specific mediators and receptors facilitated the neurobiological concept of pruritus: itch-specific (histamine-dependent and histamine-independent C-fibers); itch-specific

Evaluation of chronic pruritus in older patients

A rational work-up adapted to the special premises and needs of geriatric patients is presented, which may facilitate the choice of suitable therapeutic regimens.

Itch: a symptom of occult disease.

The systemic causes of pruritus are summarized, the assessment of a patient presenting with itch without dermatological cause is described, and the management of itch in patients with cancer is discussed.

Prevalence and clinical correlates of pruritus in patients with systemic sclerosis.

Pruritus is common in SSc and is independently associated with GI symptoms and the number of GI symptoms predicted pruritus in multiple logistic regression analysis.

[Pruritus - an important adverse drug reaction].

  • E. Weisshaar
  • Medicine
    Therapeutische Umschau. Revue therapeutique
  • 2011
Chronic pruritus is defined as itch sensations lasting longer than six weeks, which forms a major challenge in diagnostic and therapeutic respect.

Low-Dose Naltrexone for Pruritus in Systemic Sclerosis

A small case series suggests low-dose naltrexone hydrochloride (LDN) may be an effective, highly tolerable, and inexpensive treatment for pruritus and GIT symptoms in SSc.

Intractable chronic pruritus in a 67-year-old man.

Prostate cancer is demonstrated as a possible underlying disease in a patient with chronic pruritus and therapy with the selective serotonin reuptake inhibitor paroxetine significantly relievedPruritus, but was less effective when external therapy was discontinued.



Pathophysiology of pruritus in atopic dermatitis: an overview

This review highlights the recent knowledge of different mechanisms which may be involved in regulating pruritus in patients with AD potentially leading to new therapeutic applications for the treatment of itch in AD.

Uremic pruritus: A review

  • J. Lugon
  • Medicine, Biology
    Hemodialysis international. International Symposium on Home Hemodialysis
  • 2005
Inflammation and malnutrition are recognized risk factors for cardiovascular death in end‐stage renal disease patients, which may be related to the genesis of pruritus.

Paroxetine in a Case of Psychogenic Pruritus and Neurotic Excoriations

Pruritus can be the presenting symptom of a serious organic disease in absence of other clinical and laboratory abnormalities, and it is indispensable to reevaluate periodically any patient with persistent pruritus.

The Pathophysiological Puzzle of Uremic Pruritus — Insights and Speculations from Therapeutic and Epidemiological Studies

  • T. MettangC. Pauli-Magnus
  • Medicine
    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis
  • 2000
Uremic pruritus remains a frequent and sometimes tormenting problem in patients with advanced or end-stage renal insufficiency and the exact pathophysiology of UP is unknown, and systematically performed studies are lacking and hard to obtain.

Treatment of prurigo nodularis with topical capsaicin.

Topical treatment of prurigo nodularis with capsaicin with a concentration- and regimen-ranging study proved to be an effective and safe regimen resulting in clearing of the skin lesions.

Uremic Pruritus – An Update

Uremic pruritus is the itch manifesting in patients with chronic renal insufficiency, and new ideas about immunologic mechanisms are seen in recent articles, emphasizing the role of T-helper (Th) type 1 lymphocytes and interleukin (IL)-2.

Uraemic pruritus--new perspectives and insights from recent trials.

  • T. MettangC. Pauli-MagnusD. Alscher
  • Medicine
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2002
Uraemic pruritus remains a frequent and sometimes tormenting problem in patients with advanced or end-stage renal disease and, given the great clinical heterogenicity of UP, systematically performed studies are hard to obtain and are therefore sparse.

Generalized pruritus: a manifestation of iron deficiency.

Generalized pruritus may be a symptom of occult disease, and, in some disorders, it seems to be of prognostic as well as diagnostic value.

Uremic pruritus. Clinical and experimental studies.

The results suggest that the accumulation of pruritogens between dialysis sessions influences the intensity of itching, and suggests that hemodialysis patients develop an abnormal pattern of cutaneous innervation.

Treatment of PUVA itch with capsaicin

Six patients with PUVA itch were treated with capsaicin cream and five patients experienced a dramatic improvement within 48 h and complete resolution in a mean of h days (range 2-14), while the sixth patient had generalized itch, developed a severe burning sensation and treatment was discontinued.