Prunustatin A, a Novel GRP78 Molecular Chaperone Down-regulator Isolated from Streptomyces violaceoniger

@article{Umeda2005PrunustatinAA,
  title={Prunustatin A, a Novel GRP78 Molecular Chaperone Down-regulator Isolated from Streptomyces violaceoniger},
  author={Yukiko Umeda and Shuhei Chijiwa and Kazuo Furihata and Keiko Furihata and Sho-hei Sakuda and Hiromichi Nagasawa and Hidenori Watanabe and Kazuo Shin‐ya},
  journal={The Journal of Antibiotics},
  year={2005},
  volume={58},
  pages={206-209}
}
In the course of our screening program for regulators of a molecular chaperone GRP78 expression, we isolated a novel inhibitor of GRP78 expression, designated as prunustatin A, from Streptomyces violaceoniger 4521-SVS3. The structure of prunustatin A was determined by a series of NMR analyses to be an oxidized type of the neoantimycin family. Prunustatin A inhibited the expression of GRP78 induced by 2-deoxyglucose in human fibrosarcoma HT1080 cells accompanied by global cell death without… 
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