Pruning of dendrites and restoration of function after brain damage: Role of the NMDA receptor.

@article{Kozlowski1994PruningOD,
  title={Pruning of dendrites and restoration of function after brain damage: Role of the NMDA receptor.},
  author={Dorothy Annette Kozlowski and Theresa A. Jones and Timothy J Schallert},
  journal={Restorative neurology and neuroscience},
  year={1994},
  volume={7 2},
  pages={119-26}
}
Following unilateral injury to the forelimb-representation area of the sensorimotor cortex (FL-SMC) in adult rats, there occurs a biphasic process of overgrowth and partial elimination of neuronal dendrites in layer V pyramidal cells of the homotopic cortex of the opposite hemisphere. These neural events are associated with hyper-reliance on the non-impaired forelimb for postural-supporting and related movements that compensate for impaired function in the other forelimb. The overgrowth appears… CONTINUE READING

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