Prucalopride for constipation

@article{Camilleri2010PrucaloprideFC,
  title={Prucalopride for constipation},
  author={M. Camilleri and A. Deiteren},
  journal={Expert Opinion on Pharmacotherapy},
  year={2010},
  volume={11},
  pages={451 - 461}
}
Importance of the field: Chronic constipation has a high prevalence, and current medical and pharmacological therapies do not restore normal bowel function in all patients. Areas covered in the review: A PubMed search (1965 – 2009) using the following terms alone or in combination: prucalopride, 5-HT4, R093877, safety, toxicity, pharmacokinetics, pharmacodynamics, transit, cardiac, hERG, arrhythmia, potassium current, elderly. What the reader will gain: Understanding of the mechanisms of action… Expand
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