Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder.

@article{Bouras2001PrucaloprideAG,
  title={Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder.},
  author={Ernest P. Bouras and Michael Camilleri and Duane D. Burton and George M. Thomforde and Sanna McKinzie and Alan R. Zinsmeister},
  journal={Gastroenterology},
  year={2001},
  volume={120 2},
  pages={354-60}
}
BACKGROUND & AIMS Prucalopride (PRU) is a selective benzofuran 5-hydroxytryptamine(4)-receptor agonist with gastrointestinal and colonic prokinetic activities. We evaluated the effects of PRU on gastrointestinal and colonic transit in patients with constipation. METHODS Gastrointestinal and colonic transit were measured over 48 hours in 40 patients who fulfilled modified Rome I criteria for functional constipation. Patients had no evidence of a rectal evacuation disorder. Subjects were… CONTINUE READING

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