Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives

@article{Tack2008PrucaloprideI,
  title={Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives},
  author={Jan Tack and M J Van Outryve and G. Beyens and Ren{\'e} Kerstens and Lieve Vandeplassche},
  journal={Gut},
  year={2008},
  volume={58},
  pages={357 - 365}
}
Objective: To determine the efficacy, impact on quality of life (QOL) and safety of prucalopride, a selective, high-affinity 5-HT4 receptor agonist, in patients with chronic constipation. Methods: In this multicentre, randomised, placebo controlled, parallel-group, phase III study, patients with chronic constipation (two or fewer spontaneous complete bowel movements (SCBM)/week) received 2 mg or 4 mg prucalopride or placebo, once daily, for 12 weeks. The primary efficacy endpoint was the… 

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Prucalopride for the treatment of women with chronic constipation in whom standard laxative regimens have failed to provide adequate relief.

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...

References

SHOWING 1-10 OF 71 REFERENCES

A placebo-controlled trial of prucalopride for severe chronic constipation.

Over 12 weeks, prucalopride significantly improved bowel function and reduced the severity of symptoms in patients with severe chronic constipation.

Prucalopride Is Effective in Patients with Severe Chronic Constipation in Whom Laxatives Fail to Provide Adequate Relief

Once-daily prucalopride 4 mg for 4 weeks is effective and well tolerated in patients with severe CC, and improves whole gut transit, reducing straining, softening stools and reducing time to first bowel movement.

Efficacy and Tolerability of Prucalopride in Patients with Constipation due to Spinal Cord Injury

This pilot study indicates that prucalopride can play an important role in the management of patients with CC due to SCI, and a clear dose response for treatment efficacy is shown.

Lack of Objective Evidence of Efficacy of Laxatives in Chronic Constipation

It is found that large, well-controlled, published studies whose data were comparable were lacking and better evidence is required to justify the continued expenditure of funds on laxatives by both patients and formularies.

Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder.

PRU accelerates transit through the stomach, small bowel, and colon in patients with constipation unassociated with a rectal evacuation disorder, and tends to accelerate overall colonic transit with significantly faster overall Colonic transit and ascending colon emptying with the 4-mg dose.

The Treatment of Chronic Constipation in Adults

Both fiber and laxatives modestly improved bowel movement frequency in adults with chronic constipation, and there was inadequate evidence to establish whether fiber was superior to laxatives or one laxative class was inferior to another.

Psychological Well‐Being and Symptoms in Women With Chronic Constipation Treated With Sodium Picosulphate

  • M. BengtssonB. Ohlsson
  • Medicine, Psychology
    Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates
  • 2005
The use of sodium picosulphate has been restricted to a few weeks due to its potentially harmful effect on the colon. In spite of this restriction, however, many patients prefer this pharmaceutical

The treatment of chronic constipation in adults. A systematic review.

Both fiber and laxatives modestly improved bowel movement frequency in adults with chronic constipation, and there was inadequate evidence to establish whether fiber was superior to laxatives or one laxative class was inferior to another.

Quality of life in patients with different types of functional constipation.

The general well-being of patients with chronic constipation is lower than that of a comparable normal population andSymptom severity correlates negatively with perceived quality of life.

PEG 3350 (Transipeg) versus lactulose in the treatment of childhood functional constipation: a double blind, randomised, controlled, multicentre trial

PEG 3350 patients reported less abdominal pain, straining, and pain at defecation than children using lactulose, and bad taste was reported significantly more often in the PEG group, which should be the laxative of first choice in childhood constipation.
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