PrrC-anticodon nuclease: functional organization of a prototypical bacterial restriction RNase

@article{BlangaKanfi2006PrrCanticodonNF,
  title={PrrC-anticodon nuclease: functional organization of a prototypical bacterial restriction RNase},
  author={Shani Blanga-Kanfi and Michal Amitsur and Abdussalam Azem and Gabriel Kaufmann},
  journal={Nucleic Acids Research},
  year={2006},
  volume={34},
  pages={3209 - 3219}
}
The tRNA(Lys) anticodon nuclease PrrC is associated in latent form with the type Ic DNA restriction endonuclease EcoprrI and activated by a phage T4-encoded inhibitor of EcoprrI. The activation also requires the hydrolysis of GTP and presence of dTTP and is inhibited by ATP. The N-proximal NTPase domain of PrrC has been implicated in relaying the activating signal to a C-proximal anticodon nuclease site by interacting with the requisite nucleotide cofactors [Amitsur et al. (2003) Mol. Microbiol… CONTINUE READING

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