Prp8 protein: at the heart of the spliceosome.

  title={Prp8 protein: at the heart of the spliceosome.},
  author={Richard J. Grainger and Jean D. Beggs},
  volume={11 5},
Pre-messenger RNA (pre-mRNA) splicing is a central step in gene expression. Lying between transcription and protein synthesis, pre-mRNA splicing removes sequences (introns) that would otherwise disrupt the coding potential of intron-containing transcripts. This process takes place in the nucleus, catalyzed by a large RNA-protein complex called the spliceosome. Prp8p, one of the largest and most highly conserved of nuclear proteins, occupies a central position in the catalytic core of the… CONTINUE READING
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