Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication.

@article{Wong1995ProzacL,
  title={Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication.},
  author={D. Wong and F. Bymaster and E. Engleman},
  journal={Life sciences},
  year={1995},
  volume={57 5},
  pages={
          411-41
        }
}
In this review, we describe the evolutionary process involved in the discovery of the selective 5-HT uptake inhibitor, fluoxetine, and summarize some of the large body of scientific research performed on fluoxetine in the 20 years since the first publication. The historical background of the proposed involvement of 5-HT in psychiatric disorders and the activity of tricyclic antidepressants in depression is reviewed. The effects of fluoxetine in various in vitro assays and in animal studies… Expand

Paper Mentions

Blog Post
The Discovery of Fluoxetine Hydrochloride (Prozac)
Serotonin noradrenaline reuptake inhibitors: Logical evolution of antidepressant development
  • S. Montgomery
  • Medicine
  • International journal of psychiatry in clinical practice
  • 2006
Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive review
The genetics of selective serotonin reuptake inhibitors.
Blockage of muscle and neuronal nicotinic acetylcholine receptors by fluoxetine (Prozac).
Fluoxetine: a review on evidence based medicine
Molecular Basis for Selective Serotonin Reuptake Inhibition by the Antidepressant Agent Fluoxetine (Prozac)
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