Proximo-distal specification in the wing disc of Drosophila by the nubbin gene.

@article{Cifuentes1997ProximodistalSI,
  title={Proximo-distal specification in the wing disc of Drosophila by the nubbin gene.},
  author={Fuenzalida Cifuentes and Antonio Garc{\'i}a-Bellido},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 21},
  pages={
          11405-10
        }
}
Mutations in the nubbin (nub) gene have a phenotype consisting of a severe wing size reduction and pattern alterations, such as transformations of distal elements into proximal ones. nub expression is restricted to the wing pouch cells in wing discs since early larval development. These effects are also observed in genetic mosaics where cell proliferation is reduced in all wing blade regions autonomously, and transformation into proximal elements is observed in distal clones. Clones located in… CONTINUE READING
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