Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1.

@article{Vakoc2005ProximityAD,
  title={Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1.},
  author={Christopher R Vakoc and Danielle L Letting and Nele Gheldof and Tomoyuki Sawado and Michael A. Bender and Mark Groudine and Mitchell J Weiss and Job Dekker and Gerd A Blobel},
  journal={Molecular cell},
  year={2005},
  volume={17 3},
  pages={453-62}
}
Recent evidence suggests that long-range enhancers and gene promoters are in close proximity, which might reflect the formation of chromatin loops. Here, we examined the mechanism for DNA looping at the beta-globin locus. By using chromosome conformation capture (3C), we show that the hematopoietic transcription factor GATA-1 and its cofactor FOG-1 are… CONTINUE READING