Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators.

Abstract

Physiological stem cell function is regulated by secreted factors produced by niche cells. In this study, we describe an unbiased approach based on the differential single-cell gene expression analysis of mesenchymal osteolineage cells close to, and further removed from, hematopoietic stem/progenitor cells (HSPCs) to identify candidate niche factors… (More)
DOI: 10.1016/j.stem.2016.07.004

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@article{Silberstein2016ProximityBasedDS, title={Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators.}, author={Lev Silberstein and Kevin A. Goncalves and Peter V. Kharchenko and Raphael Turcotte and Youmna S. Kfoury and François E. Mercier and Ninib Baryawno and Nicolas Severe and Jacqueline Bachand and Joel A. Spencer and Ani E Papazian and Dongjun Lee and Brahmananda Chitteti and Edward F. Srour and Jonathan Hoggatt and Tiffany A Tate and Cristina Lo Celso and Noriaki Ono and Stephen L Nutt and Jyrki Heino and Kalle H Sipil{\"a} and Toshihiro Shioda and Masatake Osawa and Charles Lin and Guo-fu Hu and David T Scadden}, journal={Cell stem cell}, year={2016}, volume={19 4}, pages={530-543} }