Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients.

@article{Ciarimboli2012ProximalTS,
  title={Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients.},
  author={Giuliano Ciarimboli and Cynthia S. Lancaster and Eberhard Schlatter and Ryan M Franke and Jason A. Sprowl and Hermann J. Pavenst{\"a}dt and Vivian Massmann and Denise Guckel and Ron H. J. Mathijssen and Wenjian Yang and Ching-Hon Pui and Mary V. Relling and Edwin Herrmann and Alex Sparreboom},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2012},
  volume={18 4},
  pages={1101-8}
}
PURPOSE Knowledge of transporters responsible for the renal secretion of creatinine is key to a proper interpretation of serum creatinine and/or creatinine clearance as markers of renal function in cancer patients receiving chemotherapeutic agents. EXPERIMENTAL DESIGN Creatinine transport was studied in transfected HEK293 cells in vitro and in wild-type mice and age-matched organic cation transporter 1 and 2-deficient [Oct1/2(-/-)] mice ex vivo and in vivo. Clinical pharmacogenetic and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression.

Drug metabolism and disposition: the biological fate of chemicals • 2015
View 3 Excerpts
Highly Influenced

Organic Anion Transporter 2: An Enigmatic Human Solute Carrier.

Drug metabolism and disposition: the biological fate of chemicals • 2017
View 2 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Better nephrology for mice--and man.

Kidney international • 2010
View 16 Excerpts
Highly Influenced

New loci associated with kidney function and chronic kidney disease

Nature Genetics • 2010
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…