Proximal tubular cell synthesis and secretion of endothelin-1 on challenge with albumin and other proteins.

@article{Zoja1995ProximalTC,
  title={Proximal tubular cell synthesis and secretion of endothelin-1 on challenge with albumin and other proteins.},
  author={Carlamaria Zoja and Marina Morigi and Marina Figliuzzi and I Bruzzi and Simon D Oldroyd and Ariela Benigni and Pierre Ronco and Giuseppe Remuzzi},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={1995},
  volume={26 6},
  pages={934-41}
}
Abnormal traffic of proteins through the glomerular capillary has an intrinsic renal toxicity possibly linked to the subsequent process of over-reabsorption by proximal tubular cells. We investigated in vitro the effect of different protein concentrations on proximal tubular cell endothelin-1 (ET-1) synthesis. Rabbit proximal tubular RC.SV1 cell line was grown to confluence in serum-free hormonally defined medium. Cells were incubated for 6 and 24 hours with serum-free medium containing bovine… CONTINUE READING

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