Proximal nerve magnetization transfer MRI relates to disability in Charcot-Marie-Tooth diseases.

@article{Dortch2014ProximalNM,
  title={Proximal nerve magnetization transfer MRI relates to disability in Charcot-Marie-Tooth diseases.},
  author={Richard D. Dortch and Lindsey M. Dethrage and John C. Gore and Seth A. Smith and Jun Z. Li},
  journal={Neurology},
  year={2014},
  volume={83 17},
  pages={1545-53}
}
OBJECTIVE The objectives of this study were (1) to develop a novel magnetization transfer ratio (MTR) MRI assay of the proximal sciatic nerve (SN), which is inaccessible via current tools for assessing peripheral nerves, and (2) to evaluate the resulting MTR values as a potential biomarker of myelin content changes in patients with Charcot-Marie-Tooth (CMT) diseases. METHODS MTR was measured in the SN of patients with CMT type 1A (CMT1A, n = 10), CMT type 2A (CMT2A, n = 3), hereditary… CONTINUE READING
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