Proximal location of mouse prostate epithelial stem cells

  title={Proximal location of mouse prostate epithelial stem cells},
  author={A. Tsujimura and Y. Koikawa and S. Salm and T. Takao and S. Coetzee and D. Moscatelli and E. Shapiro and H. Lepor and T. Sun and E. Wilson},
  journal={The Journal of Cell Biology},
  pages={1257 - 1265}
  • A. Tsujimura, Y. Koikawa, +7 authors E. Wilson
  • Published 2002
  • Biology, Medicine
  • The Journal of Cell Biology
  • Stem cells are believed to regulate normal prostatic homeostasis and to play a role in the etiology of prostate cancer and benign prostatic hyperplasia. We show here that the proximal region of mouse prostatic ducts is enriched in a subpopulation of epithelial cells that exhibit three important attributes of epithelial stem cells: they are slow cycling, possess a high in vitro proliferative potential, and can reconstitute highly branched glandular ductal structures in collagen gels. We propose… CONTINUE READING
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