Prox1 is a novel coregulator of Ff1b and is involved in the embryonic development of the zebra fish interrenal primordium.

@article{Liu2003Prox1IA,
  title={Prox1 is a novel coregulator of Ff1b and is involved in the embryonic development of the zebra fish interrenal primordium.},
  author={Yi-Wen Liu and Wei Gao and H. C. Teh and J S Tan and Wing -Shing Chan},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 20},
  pages={7243-55}
}
Steroidogenic factor 1 (SF-1) plays an essential role in adrenal development, although the exact molecular mechanisms are unclear. Our previous work established that Ff1b is the zebra fish homologue of SF-1 and that its disruption by antisense morpholinos leads to a complete ablation of the interrenal organ. In this study, results of biochemical analyses suggest that Ff1b and other Ff1 members interact with Prox1, a homeodomain protein. Fine mapping using site-directed mutants showed that this… CONTINUE READING

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