Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate.

@article{Hong2002Prox1IA,
  title={Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate.},
  author={Yigwruang Hong and Natasha Harvey and Yun-Hee Noh and Vivien Schacht and Satoshi Hirakawa and Michael Detmar and Guillermo Oliver},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2002},
  volume={225 3},
  pages={
          351-7
        }
}
Early during development, one of the first indications that lymphangiogenesis has begun is the polarized expression of the homeobox gene Prox1 in a subpopulation of venous endothelial cells. It has been shown previously that Prox1 expression in the cardinal vein promotes and maintains the budding of endothelial cells that will form the lymphatic vascular system. Prox1-deficient mice are devoid of lymphatic vasculature, and in these animals endothelial cells fail to acquire the lymphatic… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 185 CITATIONS, ESTIMATED 58% COVERAGE

317 Citations

02040'02'05'09'13'17
Citations per Year
Semantic Scholar estimates that this publication has 317 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…