Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves.

Abstract

Arteries, veins, and lymphatic vessels are functionally linked, and their physical interaction is tightly regulated. The lymphatic vessels communicate with the blood vessels only at the junction of the jugular and subclavian veins. Here, we characterize the embryonic lymphovenous valves controlling this vital communication and show that they are formed by… (More)
DOI: 10.1101/gad.16974811

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