Prox1 Is a Novel Coregulator of Ff1b and Is Involved in the Embryonic Development of the Zebra Fish Interrenal Primordium

@article{Liu2003Prox1IA,
  title={Prox1 Is a Novel Coregulator of Ff1b and Is Involved in the Embryonic Development of the Zebra Fish Interrenal Primordium},
  author={Yi-Wen Liu and Wei Gao and Hui-Ling Teh and J Tan and Woon Khiong Chan},
  journal={Molecular and Cellular Biology},
  year={2003},
  volume={23},
  pages={7243 - 7255}
}
ABSTRACT Steroidogenic factor 1 (SF-1) plays an essential role in adrenal development, although the exact molecular mechanisms are unclear. Our previous work established that Ff1b is the zebra fish homologue of SF-1 and that its disruption by antisense morpholinos leads to a complete ablation of the interrenal organ. In this study, results of biochemical analyses suggest that Ff1b and other Ff1 members interact with Prox1, a homeodomain protein. Fine mapping using site-directed mutants showed… 

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...

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