Prox1 Is a Novel Coregulator of Ff1b and Is Involved in the Embryonic Development of the Zebra Fish Interrenal Primordium

@article{Liu2003Prox1IA,
  title={Prox1 Is a Novel Coregulator of Ff1b and Is Involved in the Embryonic Development of the Zebra Fish Interrenal Primordium},
  author={Yi-Wen Liu and Wei Gao and Hui-Ling Teh and J Tan and Woon Khiong Chan},
  journal={Molecular and Cellular Biology},
  year={2003},
  volume={23},
  pages={7243 - 7255}
}
ABSTRACT Steroidogenic factor 1 (SF-1) plays an essential role in adrenal development, although the exact molecular mechanisms are unclear. Our previous work established that Ff1b is the zebra fish homologue of SF-1 and that its disruption by antisense morpholinos leads to a complete ablation of the interrenal organ. In this study, results of biochemical analyses suggest that Ff1b and other Ff1 members interact with Prox1, a homeodomain protein. Fine mapping using site-directed mutants showed… Expand
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References

SHOWING 1-10 OF 103 REFERENCES
Ff1b is required for the development of steroidogenic component of the zebrafish interrenal organ.
TLDR
It is proposed that ff1b is required for the development of the steroidogenic tissue of the interrenal organ in zebrafish and could be mimicked by treatment with aminoglutethimide, an inhibitor of de novo steroid synthesis. Expand
A Zebrafish Ftz-F1 (Fushi Tarazu Factor 1) Homologue Requires Multiple Subdomains in the D and E Regions for Its Transcriptional Activity*
TLDR
It is suggested that the D and E regions of zFF1A possess both positive and negative transactivation functions, and interdomain “cross-talk” may confer the full transcriptional activity of the protein. Expand
Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development.
TLDR
The striking colocalization of SF-1 and Dax-1 supports the model that they are intimately linked in a common pathway of endocrine development. Expand
Dax1 expression is dependent on steroidogenic factor 1 in the developing gonad.
TLDR
The results show that SF1 consensus-binding sites close to the start of Dax1 transcription are important in regulating levels of expression in the developing gonad and provide novel information on how a specific enhancer element acts in different cell types at different stages of development. Expand
Zebrafish ftz-f1 gene has two promoters, is alternatively spliced, and is expressed in digestive organs.
TLDR
R reverse transcriptase-PCR and in situ hybridization experiments showed that the ff1 transcript is expressed in the hypothalamus, spinal cord, mandibular arch and digestive organs, including pancreas, liver, and intestine, implying its function in gut development. Expand
Direct Interaction of SRY-Related Protein SOX9 and Steroidogenic Factor 1 Regulates Transcription of the Human Anti-Müllerian Hormone Gene
TLDR
SOX9 is identified as an interaction partner of SF-1 that could be involved in the Sertoli cell-specific expression of AMH during embryogenesis and is proposed to be a combinatorial protein-protein and protein-DNA complex. Expand
Developmental defects of the ventromedial hypothalamic nucleus and pituitary gonadotroph in the Ftz‐F1 disrupted mice
  • K. Shinoda, Hong Lei, +9 authors E. Li
  • Biology, Medicine
  • Developmental dynamics : an official publication of the American Association of Anatomists
  • 1995
TLDR
The present results clearly showed that the hypothalamic and pituitary Ad4BPs are essential to normal development of the functional VMH and gonadotroph through some mechanism distinct from that in the peripheral steroidogenic tissues. Expand
Autoregulatory Loop in the Regulation of the Mammalian ftz-f1 Gene (*)
The mammalian ftz-f1 (mftz-f1) gene encoding Ad4BP/SF-1 has been demonstrated to be essential for the development of adrenal and gonadal glands. In a previous study, we identified an E box as theExpand
Antagonistic action of Six3 and Prox1 at the γ-crystallin promoter
TLDR
Cryg expression increases as Six3 expression decreases during ongoing lens development, and expression of Crygd/e/f is predicted to remain low at this time, while Prox1 and Six3 are present at the beginning of lens development. Expand
Segmentation gene product Fushi tarazu is an LXXLL motif-dependent coactivator for orphan receptor FTZ-F1
TLDR
It is proposed that FTZ may represent a category of LXXLL motif-dependent coactivators for nuclear receptors and that direct interaction is required for regulation of gene expression by FTZ-F1. Expand
...
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2
3
4
5
...