Prox 1 in eye degeneration and sensory organ compensation during development and evolution of the cavefish Astyanax

@article{Jeffery2000Prox1I,
  title={Prox 1 in eye degeneration and sensory organ compensation during development and evolution of the cavefish Astyanax},
  author={William R Jeffery and Allen G. Strickler and Stephanie Guiney and Deidre G. Heyser and Stanislav I. Tomarev},
  journal={Development Genes and Evolution},
  year={2000},
  volume={210},
  pages={223-230}
}
We have investigated expression of the homeobox gene Prox 1 during eye degeneration and sensory organ compensation in cavefish embryos. The teleost Astyanax mexicanus consists of sighted surface-dwelling forms (surface fish) and several populations of blind cave-dwelling forms (cavefish), which have evolved independently. Eye formation is initiated during cavefish development, but the lens vesicle undergoes apoptosis, and the eye subsequently arrests and degenerates. The requirement of Prox 1… CONTINUE READING