Provoked models of asthma: what have we learnt?

  title={Provoked models of asthma: what have we learnt?},
  author={Paul M O'Byrne and Gail M Gauvreau and John D. Brannan},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  volume={39 2},
Asthma is a chronic inflammatory disease of the airways characterized by physiological abnormalities of variable airflow obstruction and airway hyperresponsiveness (AHR) to a wide variety of physical and inhaled chemical stimuli and the presence of symptoms. AHR is measured by challenging the airways with a variety of agonists and naturally occurring stimuli, which results in constriction of the airway smooth muscle, leading to airway narrowing and airflow limitation. There are two distinct… CONTINUE READING