Provocative tests with psychostimulant drugs in schizophrenia

  title={Provocative tests with psychostimulant drugs in schizophrenia},
  author={Jeffrey A. Lieberman and John M. Kane and Jose Ma. J. Alvir},
The psychotogenic effects of psychostimulant drugs have provided a major line of evidence in support of the DA hypothesis of schizophrenia. To evaluate the effects of psychostimulant (PS) drugs inschizophrenia and the clinical variables which may influence their expression, we reviewed 36 studies of PS drugs in patients with schizophrenia. Approximately 40% evidence a psychotogenic response to PS administration in doses that are subpsychotogenic in normals. Specific clinical variables appear to… 

The amphetamine-induced sensitized state as a model of schizophrenia

Schizophrenia and psychostimulant abuse: a review and re-analysis of clinical evidence

Although the incidence of abuse in this group was high, comparisons of abuse rates generated by self-report with those obtained by urinalysis indicated that the frequency of abuse is being underestimated by 15–21%.

Is schizophrenia a dopamine supersensitivity psychotic reaction?

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  • Psychology, Medicine
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
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PharmacologicalTreatment of Substance-AbusingSchizophrenic Patients

The author discusses the role of neuroleptic medications in treating the psychotic diathesis, preventing recurrences of schizophrenic symptomatology, counteracting psychotic exacerbations engendered by abused substances, and potentially gener-ating side effects such as akinesia and akathisia that patients may attempt to "self-medicate" with substances of abuse.

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Common molecular mechanisms of sensitization phenomena must develop in these three conditions, chronic schizophrenia, psychostimulant-induced behavioral sensitization in rodents, and chronic schizophrenia are overviewed in this review.

Toxic Psychoses as Pharmacological Models of Schizophrenia

The psychotic disorders induced by psychoactive substances remain the main heuristic models of schizophrenia and go hand in hand with the common view of schizophrenia as a pathology of general cerebral disconnectivity that would affect a plurality of neurotransmitter systems.

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T he Influence of Serotonergic Modulation on Auditory Evoked Potentials ; M ismatch Negativity a Potential Translational Assay in Schizophrenia Master Thesis

Back-translate the interesting finding that increased serotonergic signaling mediated by escitalopram increases MMN amplitude in healthy volunteers by investigating the effect of increasedSerotonergic activity by dosing escitalOPram alone or in combination with 5-HT3 antagonist ondansetron in an auditory oddball paradigm in rats.

Antipsychotic Induced Dopamine Supersensitivity Psychosis: A Comprehensive Review

The update of evidence behind the classification of antipsychotic induced DSP and an investigation of its relationship to treatment resistance are reviewed.

Role of GABA Deficit in Sensitivity to the Psychotomimetic Effects of Amphetamine

GA deficits increased vulnerability to amphetamine-induced psychosis-relevant effects in healthy subjects, suggesting that pre-existing GABA deficits may explain why a subgroup of schizophrenia patients are vulnerable to AMPH.



CNS stimulants as tools in the study of schizophrenia

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The results indicate that the chronic schizophrenic patient may be hyporesponsive to amphetamine and suggest that if the dopamine hypothesis is correct, then it must be modified to take into account these findings in the chronic patient.

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It appears that methylphenidate truly effects pathological thought processes and decreases common word associations as such, rather than merely making these processes more evident by increasing verbalization.


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This topic has not been treated previously in the Annual Review of Psychology, and is chosen to emphasize the provocative effects of amphetamin e on spontaneous behavior and the biochemical and neurophysiological studies that relate primarily to these behavioral effects.

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