Provocation testing of human sperm motility using energy substrates and activators of the cyclic nucleotide system. I. Establishment of conditions for response testing.

@article{Magnus1992ProvocationTO,
  title={Provocation testing of human sperm motility using energy substrates and activators of the cyclic nucleotide system. I. Establishment of conditions for response testing.},
  author={Oystein Magnus and Thomas {\AA}byholm and Inge Bjorn Brekke and Ken Purvis},
  journal={International journal of fertility},
  year={1992},
  volume={37 2},
  pages={115-22}
}
In order to establish a series of provocation tests to evaluate the integrity of the sperm cAMP pathway, manganese (Mn), 2-deoxyadenosine (DEA) (via adenylyl cyclase), and methyl-isobutyl-xanthine (MIX) (via phosphodiesterase) were tested for their capacity to activate the progressive motility of human sperm. Optimal responses were obtained using washed… CONTINUE READING