Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite.

  title={Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite.},
  author={Kevin J. Saliba and Isabelle Ferru and Kiaran Kirk},
  journal={Antimicrobial agents and chemotherapy},
  volume={49 2},
Pantothenic acid, a precursor of the crucial enzyme cofactor coenzyme A, is one of a relatively few nutrients for which the intraerythrocytic parasite has an absolute and acute requirement from the external medium. In some organisms the provitamin pantothenol can serve as a source of pantothenic acid; however, this was not the case for the human malaria parasite Plasmodium falciparum. Instead, pantothenol inhibited the in vitro growth of P. falciparum via a mechanism that involves competition… CONTINUE READING
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