Provisional Patent Application : Hybrid System Modeling of Human Blood Clotting

  title={Provisional Patent Application : Hybrid System Modeling of Human Blood Clotting},
  author={Joseph G. Makin and Srini Narayanan and Roopa Ramamoorthi},
The process of blood coagulation in mammals is complicated, and involves the interaction of more than a dozen coagulation factors as well as a number of proteins from the kininkallikrein system and protein inhibitors. Attempts to model coagulation mathematically have previously focused on a smaller subset of interactions, perhaps one of the pathways or just a portion of one of them (cf. [1],[2], [3],[4],[5], [6] and [7]) using continuous-time chemical rate differential equations. There are… CONTINUE READING


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