Provision of Continuous Maturation Signaling to Dendritic Cells by RIG-I–Stimulating Cytosolic RNA Synthesis of Sendai Virus

@article{Okano2011ProvisionOC,
  title={Provision of Continuous Maturation Signaling to Dendritic Cells by RIG-I–Stimulating Cytosolic RNA Synthesis of Sendai Virus},
  author={Shinji Okano and Yoshikazu Yonemitsu and Ken Shirabe and Yoshihiro Kakeji and Yoshihiko Maehara and Mamoru Harada and Yasunobu Yoshikai and Makoto Inoue and Mamoru Hasegawa and Katsuo Sueishi},
  journal={The Journal of Immunology},
  year={2011},
  volume={186},
  pages={1828 - 1839}
}
Dendritic cell (DC)-based immunotherapy has potential for treating infections and malignant tumors, but the functional capacity of DC must be assessed in detail, especially maturation and Ag-specific CTL priming. Recent reports suggest that DC that are provided with continuous maturation signals in vivo after transfer into patients are required to elicit the full DC functions. We demonstrate in this study that the rSendai virus vector (SeV) is a novel and ideal stimulant, providing DC with a… 
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