Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir

@inproceedings{Bui2017ProvirusesWI,
  title={Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir},
  author={John K Bui and Michele D. Sobolewski and Brandon F Keele and Jonathan E Spindler and Andrew Musick and Ann P Wiegand and Brian T. Luke and Wei Shao and Stephen H. Hughes and John M Coffin and Mary F Kearney and John W Mellors},
  booktitle={PLoS pathogens},
  year={2017}
}
The major obstacle to curing HIV infection is the persistence of cells with intact proviruses that can produce replication-competent virus. This HIV reservoir is believed to exist primarily in CD4+ T-cells and is stable despite years of suppressive antiretroviral therapy. A potential mechanism for HIV persistence is clonal expansion of infected cells, but how often such clones carry replication-competent proviruses has been controversial. Here, we used single-genome sequencing to probe for… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 16 times over the past 90 days. VIEW TWEETS
Blog posts, news articles and tweet counts and IDs sourced by
Altmetric.com