Proviral insertions in the zebrafish hagoromo gene, encoding an F-box/WD40-repeat protein, cause stripe pattern anomalies

@article{Kawakami2000ProviralII,
  title={Proviral insertions in the zebrafish hagoromo gene, encoding an F-box/WD40-repeat protein, cause stripe pattern anomalies},
  author={Koichi Kawakami and Adam H Amsterdam and Nobuyoshi Shimoda and Thomas Becker and Jennifer Mugg and Akihiro Shima and Nancy Hopkins},
  journal={Current Biology},
  year={2000},
  volume={10},
  pages={463-466}
}
The zebrafish, Danio rerio, has three types of pigment cells (melanophores, xanthophores and iridophores) and, in adult fish, these cells are organized into a stripe pattern. The mechanisms underlying formation of the stripe pattern are largely unknown. We report here the identification and characterization of a novel dominant zebrafish mutation, hagoromo (hag), which was generated by insertional mutagenesis using a pseudotyped retrovirus. The hag mutation caused disorganized stripe patterns… CONTINUE READING

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