Protrusion force microscopy reveals oscillatory force generation and mechanosensing activity of human macrophage podosomes.

@article{Labernadie2014ProtrusionFM,
  title={Protrusion force microscopy reveals oscillatory force generation and mechanosensing activity of human macrophage podosomes.},
  author={Anna Labernadie and Ana{\"i}s Bouissou and Patrick Delobelle and St{\'e}phanie Balor and Raphael Voituriez and Amsha Proag and Isabelle Fourquaux and Christophe Thibault and Christophe Vieu and Renaud Poincloux and Guillaume M. Charri{\`e}re and Isabelle Maridonneau-Parini},
  journal={Nature communications},
  year={2014},
  volume={5},
  pages={5343}
}
Podosomes are adhesion structures formed in monocyte-derived cells. They are F-actin-rich columns perpendicular to the substrate surrounded by a ring of integrins. Here, to measure podosome protrusive forces, we designed an innovative experimental setup named protrusion force microscopy (PFM), which consists in measuring by atomic force microscopy the… CONTINUE READING