Protruding domain of capsid protein is necessary and sufficient to determine murine norovirus replication and pathogenesis in vivo.

Abstract

Human noroviruses (HuNoVs) are the major cause of epidemic, nonbacterial gastroenteritis worldwide. Due to the lack of a tractable model system and the inability to grow HuNoVs in cell culture, factors required for the norovirus (NoV) life cycle and pathogenesis in the host remain largely unknown. The discovery of murine norovirus (MNV) and the development… (More)
DOI: 10.1128/JVI.07038-11

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