Protracted bacterial bronchitis: reinventing an old disease

  title={Protracted bacterial bronchitis: reinventing an old disease},
  author={Vanessa Craven and Mark L. Everard},
  journal={Archives of Disease in Childhood},
  pages={72 - 76}
Chronic cough is common in the paediatric population, yet the true prevalence of this condition remains difficult to define. Protracted bacterial bronchitis (PBB) is a disease caused by the chronic infection of the conducting airways. In many children the condition appears to be secondary to impaired mucociliary clearance that creates a niche for bacteria to become established, probably in the form of biofilms. In others, immunodeficiencies, which may be subtle, appear to be a factor. PBB… 

Protracted bacterial bronchitis: a common problem with no agreed solution

Protracted bacterial bronchitis (PBB) is caused by a bacterial infection of the conducting airways in children who are otherwise healthy. It is the leading cause of chronic wet cough in young

Protracted bacterial bronchitis, it is a myth?

The challenge is to identify the diagnosis in children who cough without specific pointers, and refine the understanding of this condition in several facets so that patients can be treated accordingly.

An underestimated cause of chronic cough: The Protracted Bacterial Bronchitis

Protracted bacterial bronchitis (PBB) seems to be the second most common cause of chronic cough in children under 6 years of age and its main clinical feature is represented by wet cough that worsens when changing posture and improves after the introduction of antibiotics.

Pro-Con Debate: Protracted Bacterial Bronchitis as a Cause of Chronic Cough in Children.

The importance of timely diagnosis should be emphasized due to the potential that PBB may be a precursor to chronic suppurative lung disease or bronchiectasis if left untreated; however, every patient should be adequately assessed to exclude other causes of chronic cough.

Protracted bacterial bronchitis in children.

Knowing the diagnosis ofracted bacterial bronchitis may be an aid to making the correct assessment of children with chronic cough, helping to ensure that the symptoms are not misinterpreted and treated as asthma.

Protracted Bacterial Bronchitis: An Underdiagnosed Cause for Chronic Wet Cough in Children

Protracted bacterial bronchitis is defined by persistent productive cough in a child lasting for more than 4 weeks duration in the absence of symptoms or signs of other causes of chronic wet cough and which resolves following a 2–4-week course of an appropriate oral antibiotic.

[Chronic cough and protracted bacterial bronchitis in children and adolescents].

Today, PBB and non-CF bronchiectasis, i.e., bronchiectomy not caused by cystic fibrosis (CF), are two sides of a disease spectrum of suppurative lung diseases, thus, making consequent therapy and long-term pediatric pneumological support of children with chronic productive cough necessary.

The Importance of Recognizing Protracted Bacterial Bronchitis in Children

A three-year-old-boy presented to the pediatric clinic with a history of troublesome wet cough for 8 wk and the diagnosis of protracted bacterial bronchitis (PBB) was considered, which resulted in complete resolution of symptoms.

Recognition and management of children with protracted bacterial bronchitis.

Proracted bacterial bronchitis remains a clinical diagnosis causing persistent moist cough, disturbed sleep, exercise intolerance and significant levels of morbidity.



Chronic wet cough: Protracted bronchitis, chronic suppurative lung disease and bronchiectasis

In all three conditions, impaired muco‐ciliary clearance seems to be the common risk factor that provides organisms the opportunity to colonize the lower airway, and the principles of managing PBB, CSLD and bronchiectasis are the same.

Aetiology of chronic suppurative lung disease.

Investigation showed congenital malformations in six children, primary ciliary dyskinesia syndrome in seven, 11 had immunological abnormalities, and two bronchiectasis due to aspiration, and the underlying cause for the disease was found in 63%.

Outcomes in children treated for persistent bacterial bronchitis

PBB is often misdiagnosed as asthma, although the two conditions may coexist, and in addition to eliminating a persistent cough, treatment may also prevent progression to bronchiectasis.

Inflammation: a two-edged sword--the model of bronchiectasis.

  • P. Cole
  • Medicine
    European journal of respiratory diseases. Supplement
  • 1986
Chronic bronchial sepsis, of which bronchiectasis is an example, and chronic sinusitis display the hallmarks of this 'vicious circle' of host-mediated, inflammatory tissue damage and provide a useful model in man in which to ask questions, the answers to which provide valuable information about the pathogenesis of chronic inflammatory disease of the lung.

Inflammation: a two-edged sword--the model of bronchiectasis.

The answers to the questions asked provide valuable information about the pathogenesis of chronic inflammatory disease of the lung, and the hallmarks of this 'vicious circle' of host-mediated, inflammatory tissue damage are displayed.

Microbiology of Bronchoalveolar Lavage Fluid in Children With Acute Nonresponding or Recurrent Community-Acquired Pneumonia: Identification of Nontypeable Haemophilus influenzae as a Major Pathogen

Using flexible fiberoptic bronchoscopy with bronchoalveolar lavage, nontypeable Haemophilus influenzae is identified as one of the major pathogens involved in recurrent or non-responsive CAP in children.

Cough in children: definitions and clinical evaluation

Because of the favourable natural history of cough, a “positive” response in medication trials should not be assumed to be due to the medication, and children should be reassessed within the expected timeframe of response to therapy.

Bronchiectasis in childhood; prophylaxis, treatment and progress with a follow-up study of 202 cases of established bronchiectasis.

Although the clinical progress of established cases of bronchiectasis showed improvement in the majority of cases in the first two decades, it is feared that deterioration may occur in the third and fourth decades.