Protracted and variable latency of acute lymphoblastic leukemia after TEL-AML1 gene fusion in utero.

@article{Wiemels1999ProtractedAV,
  title={Protracted and variable latency of acute lymphoblastic leukemia after TEL-AML1 gene fusion in utero.},
  author={Joseph Wiemels and Anthony M. Ford and Elisabeth R van Wering and Aleida Postma and Mel Greaves},
  journal={Blood},
  year={1999},
  volume={94 3},
  pages={1057-62}
}
We report a pair of identical twins with concordant acute lymphoblastic leukemia (ALL). Unusually, their diagnoses were spaced 9 years apart at ages 5 and 14. Leukemic cells in both twins had a TEL-AML1 rearrangement, which was characterized at the DNA level by an adaptation of a long distance polymerase chain reaction (PCR) method. The genomic fusion… CONTINUE READING