Protracted, relapsing and demyelinating experimental autoimmune encephalomyelitis in DA rats immunized with syngeneic spinal cord and incomplete Freund's adjuvant.

@article{Lorentzen1995ProtractedRA,
  title={Protracted, relapsing and demyelinating experimental autoimmune encephalomyelitis in DA rats immunized with syngeneic spinal cord and incomplete Freund's adjuvant.},
  author={J C Lorentzen and Shohreh Issazadeh and Maria Storch and Manal Mustafa and H. B. Lassman and Christopher Linington and Lars Klareskog and Tomas Olsson},
  journal={Journal of neuroimmunology},
  year={1995},
  volume={63 2},
  pages={193-205}
}
Experimental autoimmune encephalomyelitis (EAE) is a model for multiple sclerosis (MS). However, MS is a chronic, relapsing and demyelinating disease, whereas EAE in rats is typically a brief and monophasic disorder showing little demyelination. We demonstrate here that DA rats develop severe, protracted and relapsing EAE (SPR-EAE) after a subcutaneous immunization at the tail base with syngeneic spinal cord and incomplete Freund's adjuvant (IFA). The neurological deficits were accompanied by… CONTINUE READING

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