Prototype development and preclinical immunogenicity analysis of a novel minimally invasive electroporation device

@article{Broderick2011PrototypeDA,
  title={Prototype development and preclinical immunogenicity analysis of a novel minimally invasive electroporation device},
  author={Kate E Broderick and Xuefei Shen and Jon Soderholm and Feng Lin and James McCoy and Aslam Sher Khan and Jian Yan and Matthew P. Morrow and Ami J Patel and Gary P Kobinger and Stephen Kemmerrer and David B. Weiner and Niranjan Y Sardesai},
  journal={Gene Therapy},
  year={2011},
  volume={18},
  pages={258-265}
}
The magnitude of the immune response to a DNA vaccine depends on three criteria—the optimized vector design, the use of a suitable adjuvant and the successful delivery and subsequent expression of the plasmid in the target tissue. In vivo electroporation (EP) has proved to be particularly effective in efficiently delivering DNA immunogens to the muscle and the skin, and indeed several devices have entered into human clinical trials. Here, we report on a novel concept of DNA delivery to the… CONTINUE READING