Prototype Nerve-Specific Near-Infrared Fluorophores

  title={Prototype Nerve-Specific Near-Infrared Fluorophores},
  author={M. H. Park and Hoon Hyun and Yoshitomo Ashitate and H. Wada and G. Park and J. Lee and Costyl N Njiojob and M. Henary and J. V. Frangioni and H. Choi},
  pages={823 - 833}
  • M. H. Park, Hoon Hyun, +7 authors H. Choi
  • Published 2014
  • Medicine
  • Theranostics
  • Nerve preservation is an important issue during most surgery because accidental transection or injury results in significant morbidity, including numbness, pain, weakness, or paralysis. Currently, nerves are still identified only by gross appearance and anatomical location during surgery, without intraoperative image guidance. Near-infrared (NIR) fluorescent light, in the wavelength range of 650-900 nm, has the potential to provide high-resolution, high-sensitivity, and real-time avoidance of… CONTINUE READING
    60 Citations
    Nerve-targeted probes for fluorescence-guided intraoperative imaging
    • 14
    • PDF
    Near-infrared nerve-binding fluorophores for buried nerve tissue imaging
    • 2
    Nile Red derivatives enable improved ratiometric imaging for nerve-specific contrast
    • 3
    • PDF
    Direct Administration of Nerve-Specific Contrast to Improve Nerve Sparing Radical Prostatectomy
    • 26
    • Highly Influenced
    • PDF


    Fluorescent peptides highlight peripheral nerves during surgery in mice
    • 155
    • Highly Influential
    • PDF
    Structure-Activity Relationship of Nerve-Highlighting Fluorophores
    • 20
    • PDF
    Intraoperative Fluorescence Imaging of Peripheral and Central Nerves Through a Myelin-Selective Contrast Agent
    • 35
    • PDF
    A NIR Dye for Development of Peripheral Nerve Targeted Probes.
    • 21
    • PDF
    Nerve-Highlighting Fluorescent Contrast Agents for Image-Guided Surgery
    • 87
    Image-guided cancer surgery using near-infrared fluorescence
    • 685
    Molecular Imaging Agents Specific for the Annulus Fibrosus of the Intervertebral Disk
    • 21
    Elucidating mechanisms of recurrent laryngeal nerve injury during thyroidectomy and parathyroidectomy.
    • 187