Protopine from Corydalis ternata has anticholinesterase and antiamnesic activities.

  title={Protopine from Corydalis ternata has anticholinesterase and antiamnesic activities.},
  author={Su-Jung Kim and Seung Yong Hwang and Young Pyo Jang and Mi Jung Park and George J. Markelonis and Tae Hwan Oh and Young Choong Kim},
  journal={Planta medica},
  volume={65 3},
While screening extracts of natural products in search of anticholinesterase activity, we found that a total methanolic extract of the tuber of Corydalis ternata (Papaveraceae) showed significant inhibitory effects on acetylcholinesterase. Further fractionation of this extract using acetylcholinesterase inhibition as the parameter screened resulted in the isolation and purification of an alkaloid, protopine. Protopine inhibited acetylcholinesterase activity in a dose-dependent manner. The… CONTINUE READING
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