Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons.

@article{Baranek2012ProtooncogeneSC,
  title={Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons.},
  author={Constanze Baranek and Manuela Dittrich and Srinivas Parthasarathy and Carine Gaiser Bonnon and Olga Britanova and Dmitriy A Lanshakov and Fatiha Boukhtouche and Julia E. Sommer and Clemencia Colmenares and Victor S Tarabykin and Suzana Atanasoski},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 9},
  pages={3546-51}
}
First insights into the molecular programs orchestrating the progression from neural stem cells to cortical projection neurons are emerging. Loss of the transcriptional regulator Ski has been linked to the human 1p36 deletion syndrome, which includes central nervous system defects. Here, we report critical roles for Ski in the maintenance of the neural stem cell pool and the specification of callosal neurons. Ski-deficient callosal neurons lose their identity and ectopically express the… CONTINUE READING

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