Protons released during pancreatic acinar cell secretion acidify the lumen and contribute to pancreatitis in mice.

@article{Behrendorff2010ProtonsRD,
  title={Protons released during pancreatic acinar cell secretion acidify the lumen and contribute to pancreatitis in mice.},
  author={Natasha Behrendorff and Matthias Floetenmeyer and Christof J. Schwiening and Peter Thorn},
  journal={Gastroenterology},
  year={2010},
  volume={139 5},
  pages={1711-20, 1720.e1-5}
}
BACKGROUND & AIMS Secretory granules are acidic; cell secretion will therefore lead to extracellular acidification. We propose that during secretion, protons co-released with proteins from secretory granules of pancreatic acinar cells acidify the restricted extracellular space of the pancreatic lumen to regulate normal physiological and pathophysiological functions in this organ METHODS Extracellular changes in pH were quantified in real time using 2-photon microscopy analysis of pancreatic… CONTINUE READING