Protons activate brain Na+ channel 1 by inducing a conformational change that exposes a residue associated with neurodegeneration.

@article{Adams1998ProtonsAB,
  title={Protons activate brain Na+ channel 1 by inducing a conformational change that exposes a residue associated with neurodegeneration.},
  author={Christopher M Adams and Peter M. Snyder and Margaret P. Price and Michael J. Welsh},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 46},
  pages={30204-7}
}
BNC1 is a mammalian neuronal cation channel in the novel DEG/ENaC ion channel family. BNC1 channels are transiently activated by extracellular protons and are constitutively activated by insertion of large residues, such as valine, in place of Gly-430; residue 430 is a site where analogous mutations in some Caenorhabditis elegans family members cause a swelling neurodegeneration. Mutation of Gly-430 to a small amino acid, cysteine, neither generated constitutive currents nor allowed… CONTINUE READING