Protons Regulate Vesicular Glutamate Transporters through an Allosteric Mechanism

@article{Eriksen2016ProtonsRV,
  title={Protons Regulate Vesicular Glutamate Transporters through an Allosteric Mechanism},
  author={Jacob Eriksen and Roger K. Chang and Matt McGregor and Katlin Silm and Toshiharu Suzuki and Robert H Edwards},
  journal={Neuron},
  year={2016},
  volume={90},
  pages={768-780}
}
The quantal nature of synaptic transmission requires a mechanism to transport neurotransmitter into synaptic vesicles without promoting non-vesicular efflux across the plasma membrane. Indeed, the vesicular transport of most classical transmitters involves a mechanism of H(+) exchange, which restricts flux to acidic membranes such as synaptic vesicles. However, vesicular transport of the principal excitatory transmitter glutamate depends primarily on membrane potential, which would drive non… CONTINUE READING
BETA
Tweets
This paper has been referenced on Twitter 8 times. VIEW TWEETS

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 56 REFERENCES

Presynaptic regulation of quantal size: K+/H+ exchange stimulates vesicular glutamate transport

  • G. Y. Goh, H. Huang, +4 authors R. H. Edwards
  • Nat. Neurosci
  • 2011
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…