Protonation equilibria of quinolone antibacterials in acetonitrile-water mobile phases used in LC.

@article{Barbosa1997ProtonationEO,
  title={Protonation equilibria of quinolone antibacterials in acetonitrile-water mobile phases used in LC.},
  author={Jos{\'e} M Filho Barbosa and Rosa Berg{\'e}s and Isabel Toro and Victoria M Sanz-Nebot},
  journal={Talanta},
  year={1997},
  volume={44 7},
  pages={1271-83}
}
Ionization constants of nine quinolone antibacterials in acetonitrile-water mixtures containing 0, 5.5, 10, 16.3, 25, 30, 40, 50 and 70% (w/w) acetonitrile were obtained and assignment of these pK values to the several potentially ionizable functional groups was made. The variation of the pK values obtained over the whole composition range studied can be explained by consideration of the preferential solvation of electrolytes in acetonitrile-water mixtures. In order to obtain pK values in any… CONTINUE READING