Proton tunnelling in hydrogen bonds and its implications in an induced-fit model of enzyme catalysis

  title={Proton tunnelling in hydrogen bonds and its implications in an induced-fit model of enzyme catalysis},
  author={Onur Pusuluk and Tristan Farrow and Cemsinan Deliduman and Keith Burnett and Vlatko Vedral},
  journal={Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences},
  • Onur Pusuluk, T. Farrow, V. Vedral
  • Published 2 March 2017
  • Chemistry, Physics
  • Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences
The role of proton tunnelling in biological catalysis is investigated here within the frameworks of quantum information theory and thermodynamics. We consider the quantum correlations generated through two hydrogen bonds between a substrate and a prototypical enzyme that first catalyses the tautomerization of the substrate to move on to a subsequent catalysis, and discuss how the enzyme can derive its catalytic potency from these correlations. In particular, we show that classical changes… 

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