Proton translocating ATPase mediated fungicidal activity of eugenol and thymol.

@article{Ahmad2010ProtonTA,
  title={Proton translocating ATPase mediated fungicidal activity of eugenol and thymol.},
  author={Aijaz Ahmad and Amber M Khan and Snowber Yousuf and Luqman Ahmad Khan and Nikhat Manzoor},
  journal={Fitoterapia},
  year={2010},
  volume={81 8},
  pages={1157-62}
}
Eugenol (1) and thymol (2) exhibit excellent fungicidal activity against pathogenic yeasts, including isolates resistant to azoles. The rapid irreversible action of compound-1 and compound 2 on fungal cells suggested a membrane-located target for their action. We investigated their effect on H(+)-ATPase mediated H(+)-pumping by various Candida species. Both compounds inhibit H(+)-ATPase activity at their respective MIC values--500 and 100 μg/ml. Glucose stimulated H(+)-extrusion was also… CONTINUE READING

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Inhibition of Escherichia coli ATP synthase by amphibian antimicrobial peptides.

International journal of biological macromolecules • 2010
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