Proton transfer in catalysis and the role of proton shuttles in carbonic anhydrase.

@article{Mikulski2010ProtonTI,
  title={Proton transfer in catalysis and the role of proton shuttles in carbonic anhydrase.},
  author={Rose L. Mikulski and David N. Silverman},
  journal={Biochimica et biophysica acta},
  year={2010},
  volume={1804 2},
  pages={422-6}
}
The undisputed role of His64 in proton transfer during catalysis by carbonic anhydrases in the alpha class has raised questions concerning the details of its mechanism. The highly conserved residues Tyr7, Asn62, and Asn67 in the active-site cavity function to fine tune the properties of proton transfer by human carbonic anhydrase II (HCA II). For example, hydrophobic residues at these positions favor an inward orientation of His64 and a low pK(a) for its imidazole side chain. It appears that… CONTINUE READING

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