Proton therapy in the management of non-Hodgkin lymphoma


Proton therapy (PT) is a highly conformal type of radiation therapy that can target the tumor while sparing dose to surrounding normal tissues. This study reviews a single institution's experience managing patients with non-Hodgkin lymphoma (NHL) treated with PT. Eleven patients with NHL were treated with PT from January 2008 to January 2014 on an institutional review board-approved outcomes tracking protocol, and included patients with indolent orbital lymphoma (n = 4), primary mediastinal B-cell lymphoma (n = 3), plasmablastic lymphoma (n = 2) and natural killer (NK) T-cell lymphoma (n = 2). The median follow-up was 38 months. The 2-year rate of local control was 91%, with one patient with NK T-cell lymphoma having recurrence in-field. Toxicities were limited to grade 2 at highest, during follow-up. PT is a feasible and effective treatment for NHL. Early outcomes are favorable. Longer follow-up and more patients are needed to confirm our findings.

DOI: 10.3109/10428194.2015.1014364
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@inproceedings{Sachsman2015ProtonTI, title={Proton therapy in the management of non-Hodgkin lymphoma}, author={Suzanne Sachsman and Stella Flampouri and Zuofeng Li and James W. Lynch and Nancy Price Mendenhall and Bradford S. Hoppe}, booktitle={Leukemia & lymphoma}, year={2015} }