Proton pump inhibitors reduce gallbladder function

  title={Proton pump inhibitors reduce gallbladder function},
  author={Mitchell A. Cahan and Lisa M Balduf and Karen J. Colton and B. Palacioz and William H. McCartney and Timothy M Farrell},
  journal={Surgical Endoscopy And Other Interventional Techniques},
BackgroundIn the authors’ previous study of gallbladder function before and after fundoplication, 58% of the patients demonstrated preoperative gallbladder motor dysfunction, and 86% of those retested after operation and cessation of proton pump inhibitors (PPIs) normalized. Because no study has directly assessed the impact of antisecretory agents on gallbladder function, this study measured gallbladder ejection fraction (GBEF) in healthy volunteers before and after initiation of PPIs.MethodsA… 

Cholecystectomy for Biliary Dyskinesia: How Did We Get There?

Functional gallbladder testing should not be seen as an indicator of relevant biliary tract disease or prognostic marker to identify patients who may benefit from operative intervention and should be considered as a part of a spectrum of functional disorders, which are generally managed conservatively.

A systemic literature review of the effect of proton pump inhibitors on gallbladder function

There are no good quality studies determining the effect of proton pump inhibitors on gallbladder function, and there is an urgent need for conducting clinical studies to address this gap in the evidence.

Evaluation of gastrointestinal pathology and treatment in children with suspected biliary dyskinesia

A trial of PPIs may be cost-effective prior to considering LC in children with acalculous biliary-type abdominal pain since four of ten children experienced a complete response to PPIs without the requirement of LC, compared with four of nine children who improved completely.

Gallbladder Ejection Fraction Declines with Age in Patients Undergoing Cholecystectomy for Acalculous Biliary Symptoms But Has Low Accuracy in the Prediction of Gallbladder Pathology

Although patients with ACBC have reduced gallbladder EF compared to the normal population, its quantitative assessment is of limited value in the prediction of gallbladders pathology.

Biliary Dyskinesia in Children and Adolescents: A Mini Review

There is a lack of consensus on the symptom profile defining biliary dyskinesia in youth and current literature does not support the use of cholescintigraphy to select patients for cholecystectomy, suggesting that more extreme cut-off values may improve the predictive value of GBEF.

Association Between Regular Use of Gastric Acid Suppressants and Subsequent Risk of Cholelithiasis: A Prospective Cohort Study of 0.47 Million Participants

Regular use of PPIs and H2RAs was associated with increased risk of cholelithiasis, and future prospective studies are required to confirm whether the observed associations are casual.

Using proton pump inhibitors increases the risk of hepato-biliary-pancreatic cancer. A systematic review and meta-analysis

The use of PPI may be associated with an increased risk of hepato-biliary-pancreatic cancer, and caution is needed when using PPIs among patients with a high risk of liver cancer.

Is There a Dark Side to Long-term Proton Pump Inhibitor Therapy?

There is no need for specific monitoring for adverse events during PPI therapy, and it is important that PPIs are only given for appropriate indications and that, whenever possible, they are used in the lowest effective dose.

Effects of Proton Pump Inhibitors and H2 Receptor Antagonists on the Ileum Motility

It was concluded that H2 receptor antagonists may be more effective than PPIs for recovering the bowel motility in the intraabdominal sepsis situation.

Investigation the relaxant effects of proton pump ınhibitors and their relaxation mechanism on sheep sphincter of Oddi

It is suggested that PPIs, especially esomeprazole, may be beneficial during the ERCP procedure and create relaxation on SO partially via Ca+2-activated potassium channels.



Gallbladder function before and after fundoplication

Effect of cholecystectomy on gastroesophageal and duodenogastric refluxFigure 1

Cholecystectomy does not result in increased bile reflux into the stomach or increased gastroesophageal acid reflux, and those patients who had increased postoperative duodenogastric reflux were entirely asymptomatic.

Constancy and variability of gallbladder ejection fraction: impact on diagnosis and therapy.

Normal and low GBEF values are reproducible in long-term studies and CCK-induced cystic duct spasm is the etiology for low EF in both CAC and CCC.

Gallbladder and gastric emptying: relationship to cholecystokininemia in diabetics.

Impaired gallbladder and gastric motility and pathological gastro‐oesophageal reflux in gallstone patients

A subgroup of gallstone patients with small—mainly asymptomatic—stones have impaired gallbladder and gastric motility as well as abnormal gastro‐oesophageal pH‐profiles, pointing to the existence of multiple functional defects of the upper gastrointestinal tract in gallstone disease.

Does gallbladder ejection fraction predict outcome after cholecystectomy for suspected chronic acalculous gallbladder dysfunction? A systematic review

Although most studies report utility of GBEF in predicting symptom outcome after cholecystectomy in patients with suspected CAGD, quality evidence is lacking, thereby precluding a definitive recommendation regarding its use.

[Effect of prolonged treatment with proton pump inhibitors on serum gastrin levels and the fundus mucosa. Preliminary results].

There were minor modifications of fundic argyrophil cell population and of gastrinaemia during the study period, but they were not related to chronic atrophic gastritis.

Pantoprazole: a new proton pump inhibitor in the management of upper gastrointestinal disease.

Clinical trials, postmarketing surveillance and long-term studies have confirmed that pantoprazole is effective and safe for the short- andlong-term management of peptic ulcer and reflux disease, with side effects similar in incidence and type to those of H(2)RAs.

Biliary dyskinesia: role of the sphincter of Oddi, gallbladder and cholecystokinin.

After quantitative cholescintigraphy, the final impression should identify the disease entity by name to assist the referring physician in making an appropriate therapeutic decision; a mere statement that a test is consistent with biliary dyskinesia is no longer sufficient.

No association between gallstones and gastroesophageal reflux disease

Gallstone disease does not seem to influence the integrity of the esophageal mucosa through GERD, and neither cholelithiasis nor cholecystectomy poses a risk for the occurrence of GERD or hiatal hernia.