Proton pump inhibitors for the treatment of cancer in companion animals

@inproceedings{Walsh2015ProtonPI,
  title={Proton pump inhibitors for the treatment of cancer in companion animals},
  author={Megan Walsh and Stefano Fais and Enrico Pierluigi Spugnini and Salvador S. Harguindey and Tareq Abu Izneid and Licia Scacco and Paula Juliet Williams and Cinzia Allegrucci and Cyril Rauch and Ziad Omran},
  booktitle={Journal of experimental & clinical cancer research : CR},
  year={2015}
}
The treatment of cancer presents a clinical challenge both in human and veterinary medicine. Chemotherapy protocols require the use of toxic drugs that are not always specific, do not selectively target cancerous cells thus resulting in many side effects. A recent therapeutic approach takes advantage of the altered acidity of the tumour microenvironment by using proton pump inhibitors (PPIs) to block the hydrogen transport out of the cell. The alteration of the extracellular pH kills tumour… CONTINUE READING
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